Without a photo, exact identification is impossible, but the creatures floating in your pothos water vase are almost certainly harmless. Common inhabitants of stagnant water include:
None of these damage the pothos (Epipremnum aureum) itself, which roots happily in water.
The best prevention and cure is replacing the water every 1–2 weeks. This:
When changing water, rinse the vase and gently rinse the roots under lukewarm tap water. Trim any mushy, brown roots before refilling.
Consider transitioning your pothos to a well-draining potting mix. Soil-grown pothos are more vigorous, less prone to root rot, and eliminate the "creature" issue entirely. If you prefer the water look, add a few drops of hydrogen peroxide (3%) per gallon during changes to suppress microbes.
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