Watering 1–2×/week for a cactus is fatal. Your Epiphyllum's yellowing leaves, spreading brown spots, and lack of blooms for 2 years all point to root rot from excess moisture.
Your west exposure (6–8 hrs sun) is perfect. Epiphyllums need high light to bloom. To trigger flowers: cool nights (50–55°F) and long nights (14 hrs darkness) in fall/winter.
Likely old sunburn or fungal lesions from past overwatering. They won't heal but won't spread if you fix the watering. Remove severely affected leaves.
Your plant can recover—Epiphyllums are resilient. The blooms will return once roots are healthy and it gets its cool/dark rest period.
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