A hanging burro's tail has a consistent, thin, wipe-off white powder over the entire plant—not spotty like powdery mildew. The owner wonders if it's natural or a problem.
Greg confirms this is normal. Many succulents and cacti produce a glaucous (waxy) coating that acts as a natural sunscreen and reduces water loss. It's especially common on plants with few spines. No treatment needed; it's a sign of a healthy, well-adapted plant.
For more detail, see the Wikipedia entry on Glaucous.
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