The huge blisters/galls on your Eastern cottonwood (Populus deltoides) are crown gall caused by Agrobacterium tumefaciens—a soil bacterium that genetically engineers plant cells to produce tumors.
Galls weaken wood at infection site. Large galls on main trunk = breakage hazard in storms. If near structures/targets, removal is prudent.
Biological control (A. radiobacter K84) only prevents infection of new plants—doesn't cure existing galls.
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