Pokeweed (Phytolacca americana) is a native perennial with a thick taproot, poisonous berries, and aggressive self-seeding.
Dig out young plants completely. For established ones, cut repeatedly to exhaust the root, or apply systemic herbicide to cut stems. Do not compost berries or roots.
Pokeweed has wildlife value, but in a home garden, the risks outweigh benefits.
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