Yes, watermelons and cucumbers can share garden space if you don't plan to save seeds. Both are cucurbits but different species (Citrullus lanatus vs. Cucumis sativus), so they won't cross-pollinate in a way that affects the current crop's fruit quality.
Both are vigorous vines. Allow at least 6–8 feet between hills or rows. Watermelon leaves are large and can shade cucumbers; trellis cucumbers vertically to improve air flow and light penetration.
With adequate space and pest management, they make compatible neighbors.
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