Mature holly with milky-white leaves dropping rapidly = powdery mildew. Flexible leaves = not dead yet, but heavily infected.
Virginia Tech fact sheet in original has detailed mildew control.
Large trees hard to spray fully—consider hiring arborist with spray equipment. But mildew rarely kills mature hollies.
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Ginkgo Tree with Small Leaves and Suckers: Cold Injury and Stress Recovery
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Pruning Young Empress Trees: Managing Suckers for Strong Structure
Tree Leaf Identification Resources for Science Projects and Homeowners
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Diagnosing Leaf Drop in Ficus Trees
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