Large black blotches on a mulberry trunk are almost certainly lichens—a symbiosis of fungi and algae. They're epiphytes (grow on bark, not in it) and don't parasitize the tree.
Do not treat lichens directly. Instead:
A denser canopy shades the bark, naturally suppressing lichens. Baking soda sprays (0.4 lb/gal) are sometimes suggested but unnecessary and potentially harmful.
Fruitless Mulberry Decline: One of Two Trees Struggling
Removing a Fruitless Mulberry Tree and Preventing Regrowth
Managing Overgrown Mulberry Trees: Pruning for Fruit Reduction
Diagnosing Two Problem Trees: Borer and Canker
Pruning a Large Multi-Trunk Mulberry Tree: Haircut, Not Topping
Identifying and Managing Slime Flux (Bacterial Wetwood) in Mature Cottonwoods
Black Walnut Fern-Like Growth: Harmless Lichens, Not a Disease
Mulberry Yellow Slime: Need Photo for Diagnosis
Fruitless Mulberry Decline Signs: Dead Branches and Loose Bark
Why Not Plant Mulberry in Urban Landscapes
Redwood Top Dieback: Internal Decay, Monitor for Hazard
15-Year-Old Mulberry Dies in 3 Months: Brix Testing and Systemic Cleanup
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