Botryosphaeria canker (caused by Botryosphaeria spp., notably B. dothidea) is a classic "stress pathogen"—it only invades woody plants already weakened by drought, freeze injury, defoliation, improper pruning, or other diseases. The fungus kills cambium and sapwood, girdling branches and causing progressive dieback. Early pruning and stress relief can save the plant; fungicides are ineffective.
Fungus lives deep in wood; sprays don't reach it. Some trunk-injection systemics (propiconazole) used commercially on high-value trees—specialized, not for home use.
Botryosphaeria is a disease of neglect. A well-cared-for tree rarely succumbs; a stressed one declines rapidly. The pruning saw and the soaker hose are your best tools.
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