The most effective time to kill a rose is during active growth when the plant is translocating nutrients to its roots. The rootstock (often the vigorous Dr. Huey) is what makes removal difficult, but it's also the pathway for herbicide.
Use a concentrated brush-on herbicide (like Roundup for shrubs) rather than a spray. Wait until the rose has several leaves, then paint the chemical onto the foliage and green canes. Ensure 48 hours of dry weather so the product moves down to the roots. This targeted approach minimizes drift damage to nearby plants.
Roundup becomes inert carbon upon hitting soil, so you can replant in the same spot. However, some roots may resprout. Monitor the area and repeat the paintbrush treatment on any new growth. Patience and persistence will win.
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