The "cancer-like" brown spots, orange discoloration spreading from leaf tips, and your watering setup (moisture-control soil + aqua globe) point to one clear culprit: chronic overwatering leading to fungal infection.
Dieffenbachia needs to dry out between waterings. Your combo keeps the soil constantly soggy—a perfect breeding ground for fungus. The roots are likely rotting.
It will recover with drier conditions. Good luck!
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