Rhoeo spathacea (Moses-in-the-cradle) naturally sheds older lower leaves as new ones form on top. Sudden mass loss or net loss = problem.
Large pot + indoor location + distilled water only = likely insufficient light and/or root rot from excess soil moisture. The pot size concern is valid—if purchased in >8" pot, it's probably okay. If you upsized, that's the problem.
This plant deserves the exact conditions it needs. Full sun is non-negotiable for Rhoeo—without it, the purple color fades, leaves thin, and decline accelerates. Correct the light first, then evaluate watering.
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