Dig out as much root mass as possible. Vinca roots are shallow but extensive. This sets it back for a year or two.
For remaining patches, apply glyphosate (Roundup) with a paintbrush or shielded sprayer to avoid hostas. Glyphosate has no soil residual; replanting is safe after 7 days.
Hostas compete well with groundcovers. Their broad leaves shade out vinca seedlings. Don't over-worry—once vinca is reduced, hostas will dominate.
Mulch 2–3 inches with compost after cleanup. Apply pre-emergent (Preen) in early spring to stop seed germination.
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