I have a 25-foot-tall Leyland cypress hedge planted on 4-foot centers. It was healthy until this summer, when needles began dying at one end. The damage starts at the bottom near the trunk and moves upward and outward, while the outermost needles stay green. What's causing this?
This classic "upward and outward" pattern is characteristic of Cercospora leaf spot, a common fungal disease in Leyland cypress and cryptomeria, especially after a damp spring and early summer. Close planting and shade worsen it. Unlike cankers that kill individual limbs, leaf spot browns the interior while branch tips remain green.
Most trees will push new needles once conditions favoring the disease subside.
For more details, see:

Leyland cypress cercospora

Leyland cypress seridium canker
Topping Leyland Cypress: Managing Height and Stability in Mature Trees
Topping Leyland Cypress Hedges: What You Need to Know
Leyland Cypress Seed Cones: Not Galls, But Sterile Seeds
Bagworm Infestation on Leyland Cypress: Act Now
Leyland Cypress Decline in Shade: Cercospora Fungus
White Jelly Blobs on Leyland Cypress: Fungal Issue?
Spittlebugs on Leyland Cypress: Contact Insecticide Before Mid-July
Planting Leyland Cypress: Acidic Soil, Holly-tone, and Split Feeding
Leyland Cypress Alternatives: Cryptomeria, ‘Green Giant’ Arborvitae, and More
Managing Overgrown Leyland Cypress: Why Topping Doesn't Reduce Width
Leyland Cypress Dieback: Seridium Canker from Drought and Cold
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